Clinical and Experimental Pediatrics

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Original Article

Cardioprotective Effects of Minocycline in Rat Myocardiac Cell Culture Induced by Hypoxia

Bum Seok Yang, Hye Jin Park, Hong Tae Kim, Jong Won Lee, Dong Suk Lee, Un Seok Nho, Hai Lee Chung, Woo Taek Kim

Clin Exp Pediatr. 2004;47(6):685-690. Published online June 15, 2004

Purpose : Minocycline appears to reduce the mortality rate of patients with myocardial infarction. Therefore, the cardioprotective effects of minocycline through reduction of apoptosis were studied in a rat myocardiac cell culture induced by hypoxia. Methods : Cultured cells from the hearts of Sprague-Dawley rats were divided into two sets of groups : normoxia groups treated with 5% O2 and...

Neuroprotective Effects of Minocycline in Rat Brain Cortical Cell Culture Induced by Hypoxia

Kyung A Ha, Bum Seok Yang, Jin Kyung Kim, Hong Tae Kim, Sung Jin Ha, Jong Won Lee, Hai Lee Chung, Woo Taek Kim

Clin Exp Pediatr. 2003;46(11):1101-1106. Published online November 15, 2003

Purpose : In vivo, minocycline appears to be neuroprotective. Thus, the neuroprotective effects of minocycline were studied in a rat brain cortical cell culture induced by hypoxia. Methods : Cultured cells from the brains of Sprague-Dawley rats were divided into two sets of groups : normoxia groups treated with 5% CO2 and hypoxia groups treated with 1% CO2. After several...

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